モルモットは身体でビタミンC (アスコルビン酸) の合成を行うことができないため、餌から補給しなければなりません。必要量は15~20mg/㎏/日で、妊娠中や授乳中のメスは30mg/kg/日以上です 〔Guide for the Care and Use of laboratory Animal 1985〕。ビタミンCは皮膚、靱帯、腱、骨、軟骨などを構成するコラーゲンの生成に関係するため 〔Udenfriend 1966,Rivers et al.1970〕、欠乏すると皮膚、血管、骨、関節に異常が現れ、食欲不振、軟便・下痢、皮膚炎ならびに被毛粗剛、歯肉炎、出血傾向、歩行障害 (肋軟骨接合部の拡大や長骨の骨端成障害) が起こります 〔Green et al.1980〕。
Cheeke PR. Nutrition of guinea pigs. In Rabbit Feeding and Nutrition. Cheeke PR ed. Academic Press. Orland. FL. p344-353. 1987.
DIRECTIVE 2010/63/EU OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 22 September 2010 on the protection of animals used for scientific purposes (科学的な目的のために使用される動物の保護に関する2010年9月22日の欧州議会及び理事会指令2010/63/EU (抄) (EUの実験動物保護指令)
Guide for the Care and Use of Laboratory Animal. U.S. Department of health, Education and Welfare. Public Health Service. NIH. 1985.
Green MD, Hawkins J, and Omaye S. Effect of scurvy on reserpine induced hypothermia in the guinea pig. Life Sci. 27. 111–116. 1980.
Henning SJ, and Hird FJR. Concentrations and metabolism of volatile fatty acids in the fermentative organs of two species of kangaroo and guinea pig. Br J Nutr. 24. 145–155. 1970.
Howe PR, Wesson LG, Boyle PE, and Wolbach SB. Low calcium rickets in the guinea pig. Proc Soc Exp Biol Med. 45. 298–301. 1940
Kaiser S, Kruger C, and Sachser N. The guinea pig. In The UFAW Handbook on the Care: Managment of Laboratory Animals 6th ed. Poole TB ed. Longman Scientific Technical. UK. p380-398. 1986.
Liu CT. Energy balance and growth rate of outbred and inbred male guinea pigs. Am J Vet Res. 49. 1752–1756. 1988.
Lister D, and McCance RA. The effect of two diets on the growth, reproduction and ultimate size of guinea pigs. Br J Nutr. 19. 311–319. 1965.
Nutrient Requirements of the Guinea Pig. Nutrient Requirements of Laboratory Animals Fourth Revised Edition. The National Academies Press. Washington DC. 1995.
Rivers JM, Krook L, and Cormier A. Biochemical and histological study of guinea pig fetal and uterine tissue in ascorbic acid deficiency. J Nutr. 100. 217–227. 1970.
Sergeev IN, Arkhapchev YP, and Spirichev VB. Ascorbic acid effects of vitamin D hormone metabolism and binding in guinea pigs. J Nutr. 120. 1185–1190. 1990.
Tsao CS, and Young M. Effect of dietary ascorbic acid on levels of serum mineral nutrients in guinea pigs. Int J Vitam Nutr Res. 59. 72–76. 1989.
Udenfriend S. Formation of hydroxyproline in collagen. Science. 152. 1335–1340. 1966.